Wörwag Pharma

Medicina, Investigación, Tecnología

Can I Use Barmicil Compuesto For Diaper Rash?

Can I Use Barmicil Compuesto For Diaper Rash
For external use only – Do not use – for the treatment of diaper rash.

What is the use of Barmicil?

What is Barmicil used for? Barmicil is the trade name of an ointment made up of three ingredients: betamethasone, clotrimazole and gentamicin. It is widely used to relieve inflammation of dermatoses that appear in response to corticosteroid therapy and that are complicated by infection by certain microorganisms.

What is hydrocortisone cream used for?

pronounced as (hye droe kor’ ti sone) Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching.

  • Hydrocortisone comes as ointment, cream, solution (liquid), spray, or lotion for use on the skin.
  • Hydrocortisone topical is usually used one to four times a day for skin problems.
  • Apply it at around the same time(s) every day.
  • Follow the directions on your prescription or product label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Use hydrocortisone exactly as directed. Do not apply more or less of it or apply it more often than prescribed by your doctor. Do not apply it to other areas of your body or use it to treat other skin conditions unless directed to do so by your doctor.

  • If your doctor has prescribed hydrocortisone for your condition, call your doctor if your symptoms do not improve in the first 2 weeks of your treatment.
  • If you obtained hydrocortisone without a prescription (over the counter) and your condition does not improve within 7 days, stop using it and call your doctor.

To use hydrocortisone topical, apply a small amount of ointment, cream, solution, spray, or lotion to cover the affected area of skin with a thin even film and rub it in gently. This medication is only for use on the skin. Do not let hydrocortisone topical get into your eyes or mouth and do not swallow it.

What is the difference between clotrimazole and betamethasone?

Descriptions – Clotrimazole and betamethasone topical combination is used to treat fungus infections. Clotrimazole works by killing the fungus or preventing its growth. Betamethasone, a corticosteroid (cortisone-like medicine or steroid), is used to help relieve redness, swelling, itching, and other discomfort of fungus infections.

  • Ringworm of the foot (tinea pedis or athlete’s foot),
  • Ringworm of the groin (tinea cruris or jock itch), and
  • Ringworm of the body (tinea corporis).

This medicine is available only with your doctor’s prescription. This product is available in the following dosage forms:

  • Cream
  • Lotion

Can clotrimazole and betamethasone be used for yeast infection?

Medicinal Benefits – BETAMETHASONE+CLOTRIMAZOLE is used to treat fungal infections, such as fungal infections, ringworm, jock itch (red and itchy rash in warm and moist areas of the body), athlete’s foot (fungal infections between toes). BETAMETHASONE+CLOTRIMAZOLE is a composition of two medicines: Betamethasone (steroid) and clotrimazole (antifungal).

Is clotrimazole cream safe?

Toxicity – When clotrimazole is applied locally and topically, toxic effects such as pelvic cramps, hives, skin rash, occasional headache, itching, and irritation of the vulva and vagina may be observed. Stop the medication if there are any adverse effects.

What is the difference between clotrimazole and hydrocortisone?

Clotrimazole belongs to a group of medicines called imidazoles which destroy the fungi and some bacteria that cause skin infections. Hydrocortisone acetate is a mild steroid which reduces swelling, redness and itching associated with inflammation of the skin.

Which drug contain Clotrimazole?

Summary Clotrimazole is a topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Brand Names Alevazol, Dermacinrx Therazole Pak, Lotriderm, Lotrimin, Lotrimin AF, Lotrisone, Mycelex Generic Name Clotrimazole DrugBank Accession Number DB00257 Background This drug is a broad spectrum antimycotic or antifungal agent.

  1. Clotrimazole’s antimycotic properties were discovered in the late 1960s 2,
  2. Clotrimazole falls under the imidazole category of azole antifungals, possessing broad-spectrum antimycotic activity 2,
  3. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets).

As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers 2, The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete’s foot 3, Weight Average: 344.837 Monoisotopic: 344.108026261 Chemical Formula C 22 H 17 ClN 2 Synonyms

  • 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
  • 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
  • 1-(o-Chlorotrityl)imidazole
  • 1-(α-(2-Chlorophenyl)benzhydryl)imidazole
  • Clotrimazol
  • Clotrimazole
  • Clotrimazolum

External IDs

  • BAY 5097
  • BAY-5097

Indication Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections 12, 15 : Tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum Candidiasis due to Candida albicans Tinea versicolor due to Malassezia furfur Diaper rash infected by Candida albicans In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid 15,

  • Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis Label,
  • It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation Label,

Troche preparations are not indicated for the treatment of any systemic mycoses Label, Reduce drug development failure rates Build, train, & validate machine-learning models with evidence-based and structured datasets. Build, train, & validate predictive machine-learning models with structured datasets. Associated Conditions

  • Balanitis candida
  • Candidiasis
  • Dermatitis
  • Erythrasma
  • Fungal Vaginal Infections
  • Fungal ear infection
  • Fungal skin infection
  • Genital candidiasis
  • Inflammation
  • Mixed Vaginal Infections
  • Oropharyngeal Candidiasis
  • Pityriasis versicolor
  • Pyoderma
  • Ringworm
  • Skin Infections
  • Skin candida
  • Tinea Corporis
  • Tinea Cruris
  • Tinea Pedis
  • Tinea inguinalis
  • Trichophytosis
  • Vaginal Candidiasis
  • Vaginal Mycosis
  • Vulvitis
  • Cutaneous candidiasis
  • Infection mycotic
  • Susceptible Bacterial Infections
  • Symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum
  • Symptomatic Tinea Cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum
  • Symptomatic Tinea Pedis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum
  • Tinea versicolor caused by Malassezia infection

Contraindications & Blackbox Warnings Avoid life-threatening adverse drug events Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more. Avoid life-threatening adverse drug events & improve clinical decision support.

Pharmacodynamics Clotrimazole is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes. The action of clotrimazole is fungistatic at concentrations of drug up to 20 mcg/mL and may be fungicidal in vitro against Candida albicans and other species of the genus Candida at higher concentrations Label,

Unfortunately, resistance to clotrimazole, which was rare in the past, is now common in various patient populations 2, Clotrimazole is generally considered to be a fungistatic, and not a fungicidal drug, although this contrast is not absolute, as clotrimazole shows fungicidal properties at higher concentrations 2,

  1. Mechanism of action Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi.
  2. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes.
  3. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane 12, 13,

Because ergosterol directly promotes the growth of fungal cells in a hormone‐like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth 2, Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as CYP51 ) 2 is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects.

Target Actions Organism
A Cytochrome P450 51 antagonist inhibitor Yeast
A Intermediate conductance calcium-activated potassium channel protein 4 inhibitor Humans
A Ergosterol inhibitor Candida albicans
U Nuclear receptor subfamily 1 group I member 2 activator Humans
U Hydroxycarboxylic acid receptor 2 partial agonist Humans

Absorption Because clotrimazole is generally not significantly absorbed, drug interactions are not a major issue with its use 2, Volume of distribution The topical form is minimally absorbed in the serum and tissues 12, Clotrimazole is a lipophilic drug 4, and has been shown to be secreted in breastmilk in animal studies 12, Improve decision support & research outcomes With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. Improve decision support & research outcomes with our structured adverse effects data.

Toxicity Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps. As with all topical agents, skin sensitization may result 12, Oral LD50 (rat) : 708 mg/kg; Intraperitoneal LD50 (rat) : 445 mg/kg; Subcutaneous LDLO (rat) : 10 g/kg; Oral LD50 (mouse) : 761 mg/kg; Subcutaneous LDLO (mouse) : 10 g/kg; Intraperitoneal LD50 (mouse) : 108 mg/kg; 16 Overdose This drug poses no risk of acute intoxication, as it is unlikely to occur following a single vaginal or dermal application of an overdose (application over a large area under conditions favorable to absorption) or accidental oral ingestion.

There is no specific antidote 13, Effects on Fertility No human studies of the effects of clotrimazole on fertility have been conducted; however, animal studies have not shown any effects on the drug on fertility 12, Use in Pregnancy There are limited data regarding the use of clotrimazole in pregnant women.

Animal studies do not show direct or indirect harmful effects on reproduction. Although the topical application of clotrimazole may result in very low serum and tissue levels, the use of clotrimazole topical cream by pregnant women is not recommended unless it is advised by the prescribing physician.

Clotrimazole topical cream should not be used in the first trimester of pregnancy unless it is considered by the physician to be essential to patient well-being 12, Use in Breastfeeding Available pharmacodynamic/toxicological studies in animals have shown excretion of clotrimazole/metabolites in breastmilk.

Clotrimazole should not be administered during breastfeeding. Although the topical application of clotrimazole has resulted in very low serum and tissue levels, the use of clotrimazole topical cream by lactating women is not recommended unless it recommended by the prescribing physician 12, Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Drug Interactions This information should not be interpreted without the help of a healthcare provider.

If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

  • Approved
  • Vet approved
  • Nutraceutical
  • Illicit
  • Withdrawn
  • Investigational
  • Experimental
  • All Drugs
Drug Interaction
Integrate drug-drug interactions in your software
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Clotrimazole.
Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Clotrimazole.
Clindamycin The metabolism of Clindamycin can be increased when combined with Clotrimazole.
Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Clotrimazole.
Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Clotrimazole.
Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Clotrimazole.
Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Clotrimazole.
Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Clotrimazole.
Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Clotrimazole.
Rimegepant The metabolism of Rimegepant can be increased when combined with Clotrimazole.

Food Interactions No interactions found. Drug product information from 10+ global regions Our datasets provide approved product information including: dosage, form, labeller, route of administration, and marketing period. Access drug product information from over 10 global regions. International/Other Brands Canesten (Bayer) / Canifug (Dr.

Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
Lotrimin Solution 10 mg/1mL Topical Physicians Total Care, Inc. 2000-11-03 2005-06-30
Lotrimin Cream 10 mg/1g Topical Physicians Total Care, Inc. 1994-11-28 2005-06-30
Mycelex Troche 10 mg/1 Oral Bayer Pharmaceuticals Corp 2006-08-14 Not applicable
Mycelex Troche 10 mg/1 Oral Physicians Total Care, Inc. 1983-06-17 2011-05-31

Generic Prescription Products

Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
Clotrimazole Lozenge 10 mg/1 Oral; Topical Hikma Pharmacuticals USA USA Inc. 2004-07-29 Not applicable
Clotrimazole Lozenge 10 mg/1 Oral Physicians Total Care, Inc. 2009-07-23 Not applicable
Clotrimazole Cream 10 mg/1g Topical Glenmark Pharmaceuticals Inc., USA 2010-08-04 Not applicable
Clotrimazole Cream 10 mg/1g Topical Proficient Rx LP 1993-08-31 Not applicable
Clotrimazole Solution 10 mg/1mL Topical Taro Pharmaceuticals U.S.A., Inc. 1996-07-29 Not applicable
Clotrimazole Solution 10 mg/1mL Topical Physicians Total Care, Inc. 1996-07-29 2011-06-30
Clotrimazole Lozenge 10 mg/1 Oral; Topical Cardinal Health 2004-07-29 2021-01-31
Clotrimazole Lozenge 10 mg/1 Oral; Topical Hikma Pharmacuticals USA USA Inc. 2004-07-29 Not applicable
Clotrimazole Lozenge 10 mg/1 Oral Padagis US LLC 2005-12-01 Not applicable
Clotrimazole Cream 10 mg/1g Topical A-S Medication Solutions 1993-08-31 Not applicable

Over the Counter Products

Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
1MED Clotrimazole 1% Antifungal Cream Cream 1 g/100g Topical QYK BRANDS LLC 2022-01-01 Not applicable
1MED Clotrimazole 1% Antifungal Cream Cream 1 g/100g Topical QYK BRANDS LLC 2022-01-01 Not applicable
Akin Anti-fungal Solution 10 mg/1mL Topical Southern Sales & Service, Inc. 2017-01-01 Not applicable
Alevazol Ointment 10 mg/1g Topical Capital Pharmaceutical, LLC 2014-09-01 Not applicable
Anti Fungal Liquid 1 g/100mL Topical Guangzhou Ertiantang Pharmaceutical Co.,ltd 2017-09-22 Not applicable
Anti-Fungal Cream 10 mg/1g Topical MPM Medical, LLC 2002-10-14 Not applicable
Anti-Fungal Cream Cream 1 g/100g Topical World Wide Services Limited Liability Company 2020-01-08 Not applicable
Antifungal Cream 10 mg/1g Topical Rite Aid Corporation 2021-02-26 Not applicable
Antifungal Cream 10 mg/1g Topical Rite Aid Corporation 2011-04-15 Not applicable
Antifungal Cream 1 g/100g Topical Safeway 2008-11-20 2017-04-14

Mixture Products

Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
ALERTREX Clotrimazole (1 g) + Dexamethasone acetate (0.04 g) + Neomycin (0.5 g) Cream Topical LABORATORIOS COASPHARMA S.A.S. 2017-04-24 2018-12-13
ANTIFUNGOL HEXAL 3 KOMBI Clotrimazole (200 mg) + Clotrimazole (10 mg/g) Kit Topical 2006-07-01 Not applicable
ANTIFUNGOL HEXAL 3 KOMBI Clotrimazole (200 mg) + Clotrimazole (10 mg/g) Kit Topical 2006-07-01 Not applicable
ANTIFUNGOL HEXAL 6 KOMBI Clotrimazole (100 mg) + Clotrimazole (10 mg/g) Kit Topical 2010-04-01 Not applicable
ANTIFUNGOL HEXAL 6 KOMBI Clotrimazole (100 mg) + Clotrimazole (10 mg/g) Kit Topical 2010-04-01 Not applicable
BETAMETASONA + CLOTRIMAZOL 1%+ NEOMICINA 0.5% Clotrimazole (1 g) + Betamethasone (0.04 g) + Neomycin (0.5 g) Cream Topical COASPHARMA S.A.S. 2017-11-24 Not applicable
BETAMETASONA/CLOTRIMAZOL/NEOMICINA CREMA Clotrimazole (1 g) + Betamethasone dipropionate (0.04 g) + Neomycin sulfate (0.5 g) Cream Topical LABORATORIO FRANCO COLOMBIANO LAFRANCOL S.A.S. 2009-02-02 Not applicable
Betamethasone Clotrimazole Clotrimazole (10 mg/1) + Betamethasone dipropionate (0.64 mg/1) Cream Topical Stat Rx USA 2002-08-02 Not applicable
CANDACORT CREAM Clotrimazole (1 % w/w) + Hydrocortisone (1 % w/w) Cream Topical ZUELLIG PHARMA PTE. LTD. 2002-02-20 Not applicable
CANDID-B CREAM Clotrimazole (1 % w/w) + Beclomethasone dipropionate (0.025 % w/w) Cream Topical UNI DRUG HOUSE 1990-02-21 Not applicable

Unapproved/Other Products

Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
Ciclomazole Clotrimazole (10 mg/1g) + Betamethasone dipropionate (0.5 mg/1g) + Ciclopirox (80 mg/1mL) Cream; Kit; Solution Topical PureTek Corporation 2020-12-17 Not applicable
DermacinRx Therazole Pak Clotrimazole (10 mg/1g) + Betamethasone dipropionate (0.5 mg/1g) + Zinc oxide (200 mg/1g) Kit Topical PureTek Corporation 2016-08-09 Not applicable
Gehwol Nail Protection Pen Clotrimazole (10 mg/1mL) Liquid Topical Eduard Gerlach Gmb H 2008-03-07 2017-04-12
Shield and Protect Anti-Fungal Clotrimazole (1.1 g/115g) Cream Topical Gentell, Inc. 2007-01-01 Not applicable
Terbinafine HCl Chlortimazole and Tolnaftate Clotrimazole (1 g/100mL) + Terbinafine hydrochloride (1 g/100mL) + Tolnaftate (1 g/100mL) Solution Topical Dr Marc’s Manufacturing And Sales 2018-01-30 2018-04-17

ATC Codes D01AC01 — Clotrimazole

  • D01AC — Imidazole and triazole derivatives
  • D01A — ANTIFUNGALS FOR TOPICAL USE
  • D01 — ANTIFUNGALS FOR DERMATOLOGICAL USE
  • D — DERMATOLOGICALS

A01AB18 — Clotrimazole

  • A01AB — Antiinfectives and antiseptics for local oral treatment
  • A01A — STOMATOLOGICAL PREPARATIONS
  • A01 — STOMATOLOGICAL PREPARATIONS
  • A — ALIMENTARY TRACT AND METABOLISM

G01AF02 — Clotrimazole

  • G01AF — Imidazole derivatives
  • G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
  • G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
  • G — GENITO URINARY SYSTEM AND SEX HORMONES

G01AF20 — Combinations of imidazole derivatives

  • G01AF — Imidazole derivatives
  • G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
  • G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
  • G — GENITO URINARY SYSTEM AND SEX HORMONES

Drug Categories Chemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety. Kingdom Organic compounds Super Class Benzenoids Class Triphenyl compounds Sub Class Not Available Direct Parent Triphenyl compounds Alternative Parents Chlorobenzenes / N-substituted imidazoles / Aryl chlorides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Hydrocarbon derivatives Substituents Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Azole / Chlorobenzene / Halobenzene / Heteroaromatic compound / Hydrocarbon derivative / Imidazole Molecular Framework Aromatic heteromonocyclic compounds External Descriptors conazole antifungal drug, imidazoles, imidazole antifungal drug, monochlorobenzenes ( CHEBI:3764 ) / a small molecule ( CPD-8926 ) Affected organisms

Yeast and other fungi

UNII G07GZ97H65 CAS number 23593-75-1 InChI Key VNFPBHJOKIVQEB-UHFFFAOYSA-N InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H IUPAC Name 1-1H-imidazole SMILES ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1 Synthesis Reference Buechel, K.H., et al; South African Patent 69/0039; January 3, 1969; assigned to Farben- Buechel, K.H., Regel, E.

  1. Ritter W: Pharmacokinetic fundamentals of vaginal treatment with clotrimazole. Am J Obstet Gynecol.1985 Aug 1;152(7 Pt 2):945-7.
  2. Crowley PD, Gallagher HC: Clotrimazole as a pharmaceutical: past, present and future. J Appl Microbiol.2014 Sep;117(3):611-7. doi: 10.1111/jam.12554. Epub 2014 Jun 30.
  3. S K, C S, Cs K, S W: Clotrimazole as a Cancer Drug: A Short Review. Med Chem (Los Angeles).2014;4(11):722-724. doi: 10.4172/2161-0444.1000219.
  4. Hashem FM, Shaker DS, Ghorab MK, Nasr M, Ismail A: Formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery. AAPS PharmSciTech.2011 Sep;12(3):879-86. doi: 10.1208/s12249-011-9653-7. Epub 2011 Jul 2.
  5. Clotrimazole Drug Summary
  6. HMDB Database
  7. The binding of Clotrimazole to the proteins of human serum
  8. Clotrimazole Cream, DailyMed
  9. FDA Approved Drug Products: Lotrisone (clotrimazole/betamethasone dipropionate) topical cream
  10. Health Canada Product Monograph: Canesten (clotrimazole) for topical and/or vaginal application
  11. Health Canada Product Monograph: Canesten (clotrimazole 1%) topical cream
  12. Canesten Monograph
  13. MedSafe NZ Data Sheet, Clotrimazole
  14. HPLC Measurement, Bbod Distribution, and Pharmacokinetics of Oral Clotrimazole, Potentially Useful Antisickling Agent
  15. Lotrisone FDA label
  16. Clotrimazole SDS

External Links Human Metabolome Database HMDB0001922 KEGG Drug D00282 KEGG Compound C06922 PubChem Compound 2812 PubChem Substance 46507927 ChemSpider 2710 BindingDB 31774 RxNav 2623 ChEBI 3764 ChEMBL CHEMBL104 ZINC ZINC000003807804 Therapeutic Targets Database DAP000138 PharmGKB PA449057 Guide to Pharmacology GtP Drug Page PDBe Ligand CL6 RxList RxList Drug Page Drugs.com Drugs.com Drug Page Wikipedia Clotrimazole PDB Entries 2xfh / 3mdv / 4xe3 / 6h1t / 6uw2 / 7axa / 7axj FDA label MSDS Clinical Trials

Phase Status Purpose Conditions Count
4 Completed Health Services Research Renal Failure, Chronic Renal Failure 1
4 Completed Treatment Bacterial Vaginosis (BV) / Candidiasis 1
4 Completed Treatment Vaginal Infections 1
4 Completed Treatment Vulvovaginal Candidiasis 2
4 Recruiting Treatment Recurrent Vulvovaginal Candidiasis 1
4 Terminated Treatment Atopic Dermatitis / Skin Diseases, Eczematous 1
4 Unknown Status Treatment Melasma 1
3 Completed Prevention Candidiasis / Fungal Infections / Human Immunodeficiency Virus (HIV) Infections 1
3 Completed Treatment Bacterial Vaginosis (BV) / Candidiasis / Vaginal Inflammation 1
3 Completed Treatment Clotrimazole / Ovulen / Vulvovaginal Candidiasis 1

Manufacturers

  • Schering plough healthcare products inc
  • Bayer pharmaceuticals corp
  • Glenmark pharmaceuticals inc usa
  • Nycomed us inc
  • Taro pharmaceuticals usa inc
  • Actavis mid atlantic llc
  • Taro pharmaceuticals inc
  • Schering corp sub schering plough corp
  • Teva pharmaceuticals usa inc
  • Bayer healthcare pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Paddock laboratories inc
  • Roxane laboratories inc

Packagers

  • Actavis Group
  • Alza Corp.
  • Bayer Healthcare
  • Bergen Brunswig
  • Cardinal Health
  • CVS Pharmacy
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • E. Fougera and Co.
  • H.J. Harkins Co. Inc.
  • Ivax Pharmaceuticals
  • Major Pharmaceuticals
  • Mckesson Corp.
  • McNeil Laboratories
  • Medisca Inc.
  • Neuman Distributors Inc.
  • Novartis AG
  • Nycomed Inc.
  • Ortho Mcneil Janssen Pharmaceutical Inc.
  • Paddock Labs
  • Palmetto Pharmaceuticals Inc.
  • PEDiNOL
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Resource Optimization and Innovation LLC
  • Rite Aid Corp.
  • Roxane Labs
  • S&P Healthcare
  • Sandhills Packaging Inc.
  • Schering Corp.
  • Schering-Plough Inc.
  • Southwood Pharmaceuticals
  • Stat Rx Usa
  • Taro Pharmaceuticals USA
  • Teva Pharmaceutical Industries Ltd.
  • Walgreen Co.
  • Warrick Pharmaceuticals Corp.

Dosage Forms

Form Route Strength
Ointment Topical 10 mg/1g
Liquid Topical 1 g/100mL
Cream Vaginal 20 mg/g
Solution Topical 1 %
Cream Vaginal 10 mg/g
Cream Topical 10 MG/G
Solution Topical 10 MG/ML
Spray Topical 10 mg/mL
Cream Topical 350 mg/35g
Lotion Topical 1 g/100mL
Solution
Cream Topical 1 mg
Cream Topical 0.01 kg/1kg
Cream Topical 1 % w/w
Lotion Topical 1 %
Cream Cutaneous; Vaginal 10 % w/w
Cream Topical
Liquid Auricular (otic) 10 mg/1ml
Cream Topical 1 % w/w
Powder Topical 1 % w/w
Solution Auricular (otic) 1 %
Solution / drops Auricular (otic)
Solution Topical 1 % w/v
Gel Vaginal
Insert Vaginal
Cream Cutaneous
Cream Topical 0.025 % w/w
Lotion Topical
Capsule; cream Oral; Topical; Vaginal
Capsule; cream Oral; Topical
Cream 1 %
Powder Topical
Cream Vaginal 10 g
Cream Vaginal 10 % w/w
Cream Topical; Vaginal 2 %
Suppository Vaginal 200 mg / sup
Solution Topical
Tablet Vaginal
Capsule Vaginal
Cream; kit; tablet Vaginal
Cream; kit Topical; Vaginal
Cream; kit; tablet Topical; Vaginal
Cream; suppository Topical; Vaginal
Cream Topical; Vaginal 1 %
Cream Topical 2 % w/w
Tablet Vaginal 0.5 g
Tablet Vaginal 200 mg/1
Liquid Topical 1 %
Cream Topical 1 g/100g
Suppository Vaginal 100 mg / sup
Suppository Vaginal 100 mg/1
Kit Topical 20 G
Suppository Vaginal 200 mg/1
Lotion Topical 1 g
Cream; kit; solution Topical
Solution Topical 10 mg/g
Spray Topical 10 mg/g
Capsule Vaginal 200 mg
Cream Vaginal 2 % w/w
Cream Vaginal 1 % w/w
Capsule; cream; kit Oral; Topical
Cream Topical 0.2 g/1g
Suspension Topical 1 g
Cream Vaginal 10 MG
Solution Topical 1 g
Insert Vaginal 100 mg
Cream Topical 1 %
Cream Vaginal 2 %
Tablet Vaginal 100 mg/1
Capsule Vaginal 1 g
Cream Topical 1000 MG
Solution Topical 1000 mg
Cream Topical 1 g/100g
Cream Topical 10 mg/1g
Cream Topical 50 mg/1g
Cream Vaginal 1 g/100g
Cream Vaginal 10 mg/1g
Cream Vaginal 100 g/1g
Liquid Topical 1 mg/1mL
Lozenge Oral 10 mg/1
Lozenge Oral; Topical 10 mg/1
Solution Topical 1 g/1mL
Solution Topical 10 mg/1mL
Cream Topical
Cream Vaginal 1 %
Capsule Vaginal
Cream Topical 10 mg
Suppository Vaginal
Cream Topical 1.00 % w/w
Capsule, liquid filled Vaginal 500 mg
Cream Vaginal 2 g/100g
Solution Topical 1 mg/1mL
Cream Topical 1 g
Cream Topical 0.01 g/1g
Powder Topical
Insert Vaginal 100 mg
Aerosol, spray Topical 1 mL/100mL
Aerosol, foam Topical 1 g/100g
Liquid Topical 10 g/1000g
Gel Topical 0.01 kg/1kg
Solution Topical 1 g/100mL
Liquid Topical 10 mg/1mL
Powder Topical 1 g
Liquid Topical 1 mg/100mL
Gel Topical 10 mg/1g
Solution Topical 0.001 g
Cream Topical 0.04 g
Spray Topical 4 mg/1mL
Powder Topical 1.0 g/100g
Cream Topical 6 mg/1mL
Solution Oral 10 mg
Spray Topical 10 mg
Capsule, liquid filled Vaginal
Tablet Oral 100 mg
Cream Vaginal
Suppository Vaginal 500 mg
Tablet Vaginal 0.1 g
Insert Vaginal 500 mg
Insert Vaginal 200 mg
Cream Vaginal 2 g
Tablet Vaginal
Aerosol Topical 1 g
Cream Topical 10 g/1g
Ointment Topical 1 mg/100g
Ointment Topical 1 g/100g
Paste Topical
Gel Topical 1 g/100g
Cream Topical 420 mg/42g
Cream Vaginal 2 g
Lotion Topical
Cream Vaginal
Insert Vaginal
Solution Vaginal
Cream
Cream Topical 2 g
Cream Topical 1.007 g
Cream Topical 1 g
Troche Oral 10 mg/1
Cream Vaginal 50 mg / 5 g
Liquid Topical 10 mg / mL
Suppository Vaginal 100 mg / tab
Cream Topical 10 mg / g
Solution Topical 10 mg / mL
Cream Topical; Vaginal 10 mg / g
Spray Topical 1 %
Cream Vaginal 1 g
Kit Topical 25 G
Cream Topical 0.5 mg/g
Cream Vaginal 10000 g
Aerosol, foam Topical 10 mg/1g
Cream Topical 1 g/100mL
Solution Oral 10 mg/ml
Cream Topical 1.0 g/100g
Ointment Topical 2.0 g/100g
Cream Topical; Vaginal 1 g
Oil Topical 10 mg/1mL
Cream Topical 10 mg/1mL
Cream Topical 0.01 mg/10g
Cream Topical 0.64 mg/g
Cream Topical 1.1 g/115g
Spray Extracorporeal 0.06 mg/30mL
Cream Topical 1 g/1g
Solution Topical
Ointment Topical 1.0 g/100g
Kit Topical
Cream Cutaneous 1 % w/w
Spray Topical
Cream Vaginal 1000 mg
Cream Topical 0.02 %
Cream Topical 10 mg/100g
Tablet Vaginal 200 mg
Tablet Vaginal 100 mg
Lozenge Oral 10 mg
Tablet Vaginal 500 mg
Cream Topical 1 %w/w
Ointment Topical 1 %w/w

Prices

Unit description Cost Unit
Clotrimazole 70 10 mg Troche Bottle 117.04USD bottle
Clotrimazole 1% Cream 45 gm Tube 49.99USD tube
Clotrimazole 1% Cream 30 gm Tube 35.99USD tube
Clotrimazole 1% Solution 30ml Bottle 24.99USD bottle
Clotrimazole 1% Cream 15 gm Tube 17.99USD tube
Clotrimazole 1% Solution 10ml Bottle 17.99USD bottle
Clotrimazole powder 5.2USD g
Mycelex 10 mg troche 1.85USD troche
Clotrimazole 10 mg troche 1.61USD troche
Mycelex-7 100 mg vaginal tablet 1.33USD tablet
Lotrimin 1% cream 1.28USD g
Gyne-lotrimin insert 1.03USD insert
Mycelex 1% cream 0.9USD g
Clotrimazole insert 0.86USD insert
Lotrimin ultra 1% cream 0.68USD g
Clotrimazole 1% cream 0.53USD g
Clotrimazole 3 2% cream 0.5USD g
Ra clotrimazole 3 cream 0.46USD g
Ra athlete’s 1% foot cream 0.37USD g
Desenex 1% cream 0.33USD g
CVS Pharmacy clotrimazole 1% cream 0.32USD g
Antifungal 1% cream 0.27USD g
Sm antifungal 1% cream 0.25USD g
Ra clotrimazole af cream 0.24USD g
Clotrim 1% vaginal cream 0.18USD g
Lotrimin af 2% spray powder 0.05USD g
Lotrimin af 2% liquid spray 0.04USD g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Not Available State Solid Experimental Properties

Property Value Source
melting point (°C) 148 MSDS
water solubility 0.49 mg/L http://www.ijpsonline.com/articles/improvement-of-solubility-and-dissolution-properties-of-clotrimazole-by-solid-dispersions-and-inclusion-complexes.pdf
logP 6.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749186/
pKa 4.1 http://www.ijpsonline.com/articles/improvement-of-solubility-and-dissolution-properties-of-clotrimazole-by-solid-dispersions-and-inclusion-complexes.pdf

Predicted Properties

Property Value Source
Water Solubility 0.00147 mg/mL ALOGPS
logP 5.48 ALOGPS
logP 5.84 Chemaxon
logS -5.4 ALOGPS
pKa (Strongest Basic) 6.26 Chemaxon
Physiological Charge Chemaxon
Hydrogen Acceptor Count 1 Chemaxon
Hydrogen Donor Count Chemaxon
Polar Surface Area 17.82 Å 2 Chemaxon
Rotatable Bond Count 4 Chemaxon
Refractivity 103.76 m 3 ·mol -1 Chemaxon
Polarizability 36.25 Å 3 Chemaxon
Number of Rings 4 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five No Chemaxon
Ghose Filter No Chemaxon
Veber’s Rule Yes Chemaxon
MDDR-like Rule No Chemaxon

Predicted ADMET Features

Property Value Probability
Human Intestinal Absorption + 0.9725
Blood Brain Barrier + 0.9837
Caco-2 permeable + 0.6858
P-glycoprotein substrate Non-substrate 0.7185
P-glycoprotein inhibitor I Non-inhibitor 0.6612
P-glycoprotein inhibitor II Non-inhibitor 0.7884
Renal organic cation transporter Non-inhibitor 0.5854
CYP450 2C9 substrate Non-substrate 0.7898
CYP450 2D6 substrate Non-substrate 0.9149
CYP450 3A4 substrate Non-substrate 0.6262
CYP450 1A2 substrate Inhibitor 0.9106
CYP450 2C9 inhibitor Inhibitor 0.8948
CYP450 2D6 inhibitor Inhibitor 0.8932
CYP450 2C19 inhibitor Inhibitor 0.8994
CYP450 3A4 inhibitor Inhibitor 0.8478
CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.9799
Ames test Non AMES toxic 0.7428
Carcinogenicity Non-carcinogens 0.9018
Biodegradation Not ready biodegradable 1.0
Rat acute toxicity 2.7194 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9659
hERG inhibition (predictor II) Inhibitor 0.6779

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. ( 23092397 ) Mass Spec (NIST) Not Available Spectra

Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum – GC-MS Predicted GC-MS Not Available
Mass Spectrum (Electron Ionization) MS splash10-004i-1490000000-442fa75d6a2d80321e36
MS/MS Spectrum – Quattro_QQQ 10V, N/A LC-MS/MS splash10-004i-0090000000-9ac001e37a55e61bc916
MS/MS Spectrum – Quattro_QQQ 25V, N/A LC-MS/MS splash10-004i-0290000000-6285150b307e50af52c7
MS/MS Spectrum – Quattro_QQQ 40V, N/A LC-MS/MS splash10-016u-0690000000-5814802384fae84ca3df
Predicted MS/MS Spectrum – 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum – 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum – 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum – 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum – 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum – 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
LC-MS/MS Spectrum – LC-ESI-ITFT, positive LC-MS/MS splash10-004i-0090000000-23b69c41217f6b148307
LC-MS/MS Spectrum – LC-ESI-ITFT, positive LC-MS/MS splash10-016r-0960000000-5b3632c056ca1c0fa601
LC-MS/MS Spectrum – LC-ESI-ITFT, positive LC-MS/MS splash10-016r-0950000000-bcb189995c8cdcd62304
LC-MS/MS Spectrum – LC-ESI-ITFT, positive LC-MS/MS splash10-004i-0090000000-f1d5f44ac74388f9bf4f
MS/MS Spectrum -, positive LC-MS/MS splash10-004i-1490000000-1ed188e9911ad62a7fc7
MS/MS Spectrum -, positive LC-MS/MS splash10-004i-0390000000-c2f0490842646cf25d56
MS/MS Spectrum -, positive LC-MS/MS splash10-014l-3970000000-0cf80068015e539b67c9
LC-MS/MS Spectrum – LC-ESI-QFT, positive LC-MS/MS splash10-00or-0391000000-e8d9d4c77703a87fdcd8
1H NMR Spectrum 1D NMR Not Applicable
2D NMR Spectrum 2D NMR Not Applicable

Can you use hydrocortisone cream on babies for diaper rash?

The best treatment for diaper rash is to keep your baby’s skin as clean and dry as possible. If the rash doesn’t go away with home treatment, your health care provider might suggest:

A mild (0.5% to 1%) hydrocortisone (steroid) cream twice a day for 3 to 5 days An antifungal cream, if your baby has a fungal infection Antibiotic medicine taken by mouth, if your baby has a bacterial infection

A diaper rash might take several days to improve, depending on how severe it is. A rash may come back again and again. If a rash persists even with prescription products, your health care provider may recommend that your baby see a specialist in skin conditions (dermatologist).

Is hydrocortisone cream safe for babies?

3. Who can and cannot use hydrocortisone skin treatments – Most adults and children aged 10 years and over can use hydrocortisone skin treatments. Do not use hydrocortisone skin treatments on children under 10 years old unless their doctor recommends it. Hydrocortisone is not suitable for some people. Tell your pharmacist or doctor before starting the medicine if you:

  • have ever had an allergic reaction to hydrocortisone or any other medicine
  • have a skin infection or eye infection
  • are trying to get pregnant, are already pregnant or you’re breastfeeding

Where should you not use hydrocortisone cream?

What Can I Use It For? – Hydrocortisone is useful for different types of dermatitis or skin inflammations caused by such allergens or irritants as soap, detergents, cosmetics, jewelry, and poison ivy, oak, or sumac. The skin affected with these problems may appear to have a rash, be broken out with blisters, be affected with raw areas, or have a dry, scaly appearance.

  • Hydrocortisone can help stop itching of the skin and genital or anal areas, and it also helps relieve the discomfort from insect bites.
  • In addition, it is of some use in psoriasis or seborrheic dermatitis.
  • The product should be applied three to four times daily.
  • It is important to avoid incorrect usage of this product.

Hydrocortisone should not be used for the following conditions without a physician’s advice: diaper rash, female itching when there is a vaginal discharge, vaginal thrush, any form of fungal skin infection (i.e., athlete’s foot, ringworm of the body, jock itch), burns, acne, dandruff, hair loss, warts, corns, calluses, sunburn, or any other condition not specifically mentioned on the label.

How fast does clotrimazole and betamethasone work?

How does this medication work? What will it do for me? – This combination product contains two medications: betamethasone and clotrimazole. It is used to treat itchy, inflamed skin rashes caused by certain types of fungus (e.g., athlete’s foot, jock itch, ringworm).

  1. Betamethasone belongs to the group of medications called corticosteroids and it works by decreasing inflammation.
  2. Clotrimazole belongs to the group of medications called antifungals and it works by killing certain types of fungus.
  3. Once treatment is started, itching and redness are usually relieved within 3 to 5 days.

If relief does not occur after 1 week of use for jock itch or ringworm, contact your doctor. If relief does not occur after 2 weeks of use for athlete’s foot, contact your doctor. This medication may be available under multiple brand names and/or in several different forms.

  • Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.
  • As well, some forms of this medication may not be used for all of the conditions discussed here.
  • Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.

If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do.

What are the side effects of clotrimazole and betamethasone cream?

Betamethasone and clotrimazole topical side effects – Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Betamethasone and clotrimazole topical may cause serious side effects. Call your doctor at once if you have:

worsening of your skin condition; redness, warmth, swelling, oozing, or severe irritation of any treated skin; blurred vision, tunnel vision, eye pain, or seeing halos around lights; high blood sugar-increased thirst, increased urination, dry mouth, fruity breath odor; or possible signs of absorbing this medicine through your skin-weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects of betamethasone and clotrimazole topical may include:

numbness, tingling, or stinging; skin dryness or rash; swelling; or new infections.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is a good substitute for clotrimazole?

Similarly to how different types of viruses can cause multiple different viral infections, there are many types of fungi that can cause different types of fungal infections. It is often a difficult task to determine which antifungal product may be the most appropriate to utilize for a specific situation.

  • Although there are many different types of fungi that can cause infections, tinea infections are the fungal infections that are most treatable by non-prescription medicines.
  • So, those infections are especially highlighted in this article.
  • The purpose of this article is to aid in product selection once it is determined that a fungal infection may be present.

This article does not discuss how to identify if an infection of unknown cause may be of fungal origin. The following are examples of credible resources that may help to decide if experienced symptoms may point toward the direction of a fungal infection.

  • This resource from the Centers for Disease Control and Prevention (CDC) provides a quality introduction to fungal infections and their etiology
  • This resource from MedlinePlus (US National Library of Medicine) provides further background on diagnostics and signs and symptoms to be aware of
  • This resource from an academic medical center details tinea infections specifically
  • Your local pharmacist and physician are essential resources

Remember, for many minor fungal infections, it is appropriate to utilize an antifungal medicine that can be purchased over-the-counter at a pharmacy or online. But, for more serious fungal infections, it is recommended to see a physician to obtain a specific recommendation.

  • All OTC antifungal products discussed here are products that are applied topically to the skin and/or vaginal area.
  • Topical OTC antifungal products tend to have similar indications, and they commonly can be substituted for one another.
  • However, the list below describes popular topical OTC antifungal medicines and it provides an introduction on how to differentiate between products.1.

Clotrimazole Clotrimazole is one of the most common topical antifungal medicines sold at pharmacies. Clotrimazole is commonly sold as a generic product, but it is also available under the brand names of Alevazol, Lotrimin AF, Gyne-Lotrimin, etc. Clotrimazole can be used to treat either skin-based or vaginal fungal infections.

It is used to treat tinea corporis (ringworm), tinea cruris (fungal infection in the groin or buttocks area; often called «jock itch»), tinea pedis (fungal infection on the foot; often called «athlete’s foot»), or vulvovaginal candidiasis (vaginal fungal infection; often called a «yeast infection»).

Clotrimazole is available as a skin cream, ointment, external liquid solution, and vaginal cream. Clotrimazole is very similar to miconazole, discussed below. Clotrimazole and miconazole fall into the same category of antifungals.2. Miconazole Miconazole is another common antifungal agent, and it is available as a generic product and under many different brand names (Desenex, Micaderm, Monistat, etc).

  1. Miconazole is an antifungal drug of choice for vaginal yeast infections.
  2. It can also be used to treat ringworm, jock itch, or athlete’s foot.
  3. Miconazole is available as an aerosol, aerosol powder, skin cream, vaginal cream, ointment, powder, external liquid solution, and vaginal suppository.
  4. Creams and solutions for nonprescription antifungals are typically more effective than powders and aerosols.

Miconazole is very similar to clotrimazole, discussed above. Thus, the effectiveness of miconazole is comparable to clotrimazole. Clotrimazole is utilized more commonly for skin infections and miconazole is utilized more commonly for vaginal infections, but both can be used for either purpose.

Clotrimazole and miconazole are both used twice per day for up to 4 weeks. Both of these products can be used in individuals 2 years of age or older. FAST FACT: A frequently asked question relates to the difference between Monistat 1, Monistat 3, and Monistat 7. All three are vaginal miconazole products.

Monistat 1 is a single-day, single-dose regimen with a miconazole dose of 1200 mg. Monistat 3 is a three-day, three-dose regimen that has a concentration of 200 mg per dose of miconazole. Monistat 7 is a low dose, seven-day, seven-dose regimen that contains an even lower concentration of miconazole (100 mg per dose).

  1. All regimens are noted to be equally effective, but it is recommended to ask a local pharmacist about which regimen may be most appropriate for a specific individual.3.
  2. Tolnaftate Tolnaftate is commonly sold as a generic product, but it is an antifungal medicine also available under brand names such as Fungi-Guard, Tinactin, Tinaspore, etc.

Whereas the other medicines prior mentioned have been noted to be used for treatment, tolnaftate can be used for both prevention and treatment of athlete’s foot. It can also be used for the treatment of ringworm and jock itch. Tolnaftate is available as an aerosol, aerosol powder, cream, powder, and external liquid solution.

Creams and solutions for nonprescription antifungals are typically more effective than powders and aerosols. Tolnaftate is used twice per day for up to 4 weeks. Tolnaftate can be used in individuals 2 years of age or older. However, there is little evidence that prioritizes its use over clotrimazole or miconazole.

Clotrimazole, for example, is noted to be a newer medicine that is slightly more effective than tolnaftate.4. Butenafine Butenafine is an antifungal medicine with common brand names of Lotrimin Ultra and Mentax, although it is often sold as a generic product.

  1. Butenafine is used for skin-based fungal infections.
  2. It is used to treat ringworm, jock itch, or athlete’s foot.
  3. Butenafine is available as an external cream.
  4. Butenafine and terbinafine fall into slightly different antifungal medicine categories, but they are similar and largely interchangeable for most purposes.

More about their relationship is described below.5. Terbinafine Terbinafine is an antifungal medicine with the common brand names of Lamisil Advanced and Lamisil AT. Terbinafine is also used for skin-based fungal infections. It is used to treat ringworm, jock itch, or athlete’s foot.

  • Terbinafine is available as a cream, gel, and external liquid solution.
  • Both butenafine and terbinafine may be preferable options compared to clotrimazole, miconazole, and tolnaftate for athlete’s foot specifically.
  • Butenafine and terbinafine are often more expensive than clotrimazole or miconazole.
  • If cost is an issue (namely for the treatment of athlete’s foot), a switch to clotrimazole or miconazole is appropriate.

However, their effectiveness is comparable to clotrimazole and miconazole regarding ringworm and jock itch. For athlete’s foot primarily on the sides and bottoms of the feet, the creme is the preferred formulation for both butenafine and terbinafine. Butenafine and terbinafine are used 1-2 times daily for up to 4 weeks.

Both of these products can be used in individuals aged 12 years or older.6. Undecylenic acid Undeclylenic acid is an antifungal medicine commonly sold under its generic name, but it is also sold under the brand names Fungi-Nail, Myco Nail A, etc. Undecylenic acid is also used for skin-based fungal infections.

Undecylenic acid is available as a gel, external liquid solution, ointment, spray, and solution. Although it can be used for ringworm or jock itch, undecylenic acid is commonly used around the nail cuticles and/or the skin around the nails to prevent fungal growth.

It may also be used to treat athlete’s foot. It is applied twice daily for 4 weeks, and the minimum age for use is 2 years.7. Ketoconazole Ketoconazole is available in many different dosage forms, but the OTC version of ketoconazole is a shampoo sold under the brand name Nizoral A-D. Nizoral A-D is a medicine that is used to help control dandruff,

Ketoconazole is a potent antifungal agent, but other dosage forms of ketoconazole require the advice and direction of a physician, Nizoral A-D can be applied every 3-4 days for up to 8 weeks. Resources:

  1. Fungal Diseases. Centers for Disease Control and Prevention (CDC). Last updated 19 March 2020. Accessed 28 March 2020.
  2. Ely JW, Rosenfeld S, Seabury Stone M. Diagnosis and Management of Tinea Infections. Am Fam Physician,2014 Nov 15;90(10):702-711.
  3. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev,2007 Jul 18;(3):CD001434.
  4. Weinstein A, Berman B. Topical Treatment of Common Superficial Tinea Infections. Am Fam Physician,2002 May 15;65(10):2095-2103.
  5. Hart R, Bell-Syer SE, Crawford F, Torgerson DJ, Young P, Russell I. Systematic review of topical treatments for fungal infections of the skin and nails of the feet. BMJ,1999;319(7202):79–82. doi:10.1136/bmj.319.7202.79
  6. McKeny PT, Zito PM. Antifungal Antibiotics., In: StatPearls,Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538168/

Can I use clotrimazole cream on Pennis?

It can be used to treat the external symptoms of thrush (vulval candidiasis). It may also be used by the woman’s sexual partner to treat associated penile thrush (candidal balanitis). Thrush may be aggravated by sexual intercourse, but is not a sexually transmitted disease.

How long to use clotrimazole and betamethasone cream?

Treatment for 2 weeks on the groin or on the body, and for 4 weeks on the feet is recommended. The use of Clotrimazole and Betamethasone Dipropionate Cream for longer than 4 weeks is not recommended for any condition. Prolonged use of Clotrimazole and Betamethasone Dipropionate Cream may lead to unwanted side effects.

How many times should I use clotrimazole cream for yeast infection?

Clotrimazole comes as a 1% strength cream, spray or solution. Apply clotrimazole to the affected area 2 to 3 times a day. It will work better if you can use it 3 times a day.

When is the best time to use clotrimazole?

The cream is inserted into the vagina once a day at bedtime for 3 or 7 days in a row, depending on the product instructions. The cream is used twice a day for up to 7 days around the outside of the vagina.

What happens when you insert clotrimazole?

This medication is used to treat vaginal yeast infections. Clotrimazole reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection.

What happens when you apply clotrimazole?

Clotrimazole is an antifungal medicine. It’s used to treat skin infections caused by a fungus (yeast). It works by killing the fungus that is causing the infection. Clotrimazole treats different types of fungal infections, including:

athlete’s foot ringworm fungal nail infection infected nappy rash rash in folds of skin (intertrigo)

Clotrimazole is available as a cream, spray and a solution that you put on your skin. The treatment you use will depend on where the infection is on your body. You can buy clotrimazole from a pharmacy or shop. Clotrimazole is also available as external and internal cream and pessaries, to treat vaginal thrush,